Fructose and glucose sound pretty similar, and both even taste sweet, but it turns that they affect your brain in very different ways. This new study from Yale University examined the individual effects of fructose and glucose by conudcting MRI scans after ingestion of each sugar. The results revealed that glucose led to much greater reduction in the hypothalamus, the brain region that regulates appetite and reward processing, and greater feelings of satiety. On the other hand, sucrose ingestion demonstrated less reduction in the hypothalamus and lower levels of the hormone that regulates satiety. These findings suggest that even though they both taste sweet, sucrose may actually increase our appetite and eating.